Article

KSR1- and ERK-dependent Translational Regulation of the Epithelial-to-Mesenchymal Transition

2021-01-21

Abstract excerpt

The epithelial-to-mesenchymal transition (EMT) is considered a transcriptional process that induces a switch in cells from a polarized state to a migratory phenotype. Here we show that KSR1 and ERK promote EMT through the preferential translation of Epithelial-Stromal Interaction 1 (EPSTI1), which is required to induce the switch from E-to N-cadherin and coordinate migratory and invasive behavior. EPSTI1 is overex...

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Literature Corpus work: 41492648-d2cb-5d81-a5fa-0d40b74d3643
DOI: 10.1101/2021.01.18.427224

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