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The Role of RKIP in the Regulation of EMT in the Tumor Microenvironment

22 Sept 2022

Abstract excerpt

The Raf Kinase Inhibitor Protein (RKIP) is a unique gene product that directly inhibits the Raf/Mek/Erk and NF-kB pathways in cancer cells and resulting in the inhibition of cell proliferation, viability, EMT, and metastasis. Additionally, RKIP is involved in the regulation of cancer cell resistance to both chemotherapy and immunotherapy. The low expression of RKIP expression in many cancer types is responsible,...

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PMID: 36230521
DOI: 10.3390/cancers14194596

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