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Article

A Staphylococcus aureus fitness test platform for mechanism-based profiling of antibacterial compounds.

Chemistry & biology - 28 Aug 2009

Donald Robert G K, Skwish Stephen, Forsyth R Allyn, Anderson Jennifer W, Zhong Tanya, Burns Colleen, Lee Suzy, Meng Xin, LoCastro Lynn, Jarantow Lisa Wang, Martin Jesus, Lee Sang Ho, Taylor Ian, Robbins David, Malone Cheryl, Wang Liangsu, Zamudio Carlos S, Youngman Philip J, Phillips John W

Abstract excerpt

The emergence of drug-resistant bacteria coupled with the limited discovery of novel chemical scaffolds and druggable targets inspires new approaches to antibiotic development. Here we describe a chemical genomics strategy based on 245 Staphylococcus aureus antisense RNA strains, each engineered for reduced expression of target genes essential for S. aureus growth. Attenuation of gene expression can sensitize...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 19716473
DOI: 10.1016/j.chembiol.2009.07.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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