Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Validation of antibacterial mechanism of action using regulated antisense RNA expression in Staphylococcus aureus.

FEMS microbiology letters - 16 Feb 2004

Ji Yinduo, Yin Dezhong, Fox Brian, Holmes David J, Payne David, Rosenberg Martin

Abstract excerpt

Validation of antibiotic mode of action in whole bacterial cells is a key step for antibiotic drug discovery. In this study, one potential drug target, enoyl-acyl carrier protein reductase (FabI), an essential enzyme in the fatty acid biosynthesis pathway, was used to evaluate the feasibility of using a regulated antisense RNA interference approach to determine antibiotic mode of action. Antisense isogenic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anti-Bacterial Agents
Share to Drug Resistance, Multiple

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Enzyme Inhibitors

Share to Mutagenesis

Share to Oxidoreductases

Share to Phenotype

Share to RNA, Antisense

Share to Staphylococcus aureus

Source

Identifiers

PMID: 14987762
DOI: 10.1016/S0378-1097(03)00931-5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Validation of antibacterial mechanism of action using regulated antisense RNA expression in Staphylococcus aureus.PMID 14987762Read ↗

<i>Staphylococcus aureus</i> TargetArray: Comprehensive Differential Essential Gene Expression as a Mechanistic Tool To Profile AntibacterialsSemantic proximity Read ↗

Identification of critical staphylococcal genes using conditional phenotypes generated by antisense RNA.Semantic proximity Read ↗

Genomic analysis using conditional phenotypes generated by antisense RNA.Semantic proximity Read ↗

A Staphylococcus aureus fitness test platform for mechanism-based profiling of antibacterial compounds.Semantic proximity Read ↗

A genome‐wide strategy for the identification of essential genes in <i>Staphylococcus aureus</i>Semantic proximity Read ↗

RNAIII suppresses the expression of LtaS via acting as an antisense RNA in Staphylococcus aureus.Semantic proximity Read ↗

A broad range quorum sensing inhibitor working through sRNA inhibition.Semantic proximity Read ↗

Inducible Expression of a Resistance-Nodulation-Division-Type Efflux Pump in Staphylococcus aureus Provides Resistance to Linoleic and Arachidonic Acids.Semantic proximity Read ↗

Regulated gene expression in Staphylococcus aureus for identifying conditional lethal phenotypes and antibiotic mode of action.Semantic proximity Read ↗

IMPROVED PROBE-BASED ASSAY FOR THE QUANTIFICATION OF STAPHYLOCOCCUS AUREUS VIRULENCE REGULATOR, RNAIII, BOTH IN VITRO AND IN VIVOSemantic proximity Read ↗

Meleagrin, a new FabI inhibitor from Penicillium chryosogenum with at least one additional mode of action.Semantic proximity Read ↗

Acquired Nisin Resistance in Staphylococcus aureus Involves Constitutive Activation of an Intrinsic Peptide Antibiotic Detoxification ModuleSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.