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Article

Loss of peroxisome proliferator-activated receptor gamma in mouse fibroblasts results in increased susceptibility to bleomycin-induced skin fibrosis.

Arthritis and rheumatism - 1 Sept 2009

Kapoor Mohit, McCann Matthew, Liu Shangxi, Huh Kun, Denton Christopher P, Abraham David J, Leask Andrew

Abstract excerpt

OBJECTIVE: There is increasing evidence that the transcription factor peroxisome proliferator-activated receptor gamma (PPARgamma) plays an important role in controlling cell differentiation, and that PPARgamma ligands can modify inflammatory and fibrotic responses. The aim of the present study was to examine the role of PPARgamma in a mouse model of skin scleroderma, in which mice bearing a fibroblast-specific...

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Identifiers

PMID: 19714649
DOI: 10.1002/art.24761

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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