Article

Loss of PPARγ Expression and Signaling Is a Key Feature of Cutaneous Actinic Disease and Squamous Cell Carcinoma: Association With Tumor Stromal Inflammation

2024-07-02

Abstract excerpt

Given the importance of peroxisome proliferator-activated receptor (PPAR)-gamma in epidermal inflammation and carcinogenesis, we analyzed transcriptomic changes observed in epidermal PPARγ deficient mice (Pparg-/-epi). Gene set enrichment analysis revealed a close association with epithelial malignancy, inflammatory cell chemotaxis and cell survival. Single cell sequencing of Pparg-/-epi mice verified change...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 195093b8-f36a-5c8f-a11f-71c593e8b2f5
DOI: 10.20944/preprints202407.0153.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Loss of PPARγ Expression and Signaling Is a Key Feature of Cutaneous Actinic Disease and Squamous Cell Carcinoma: Association With Tumor Stromal InflammationDOI 10.20944/preprints202407.0153.v1Read

Epidermal PPARγ Is a Key Homeostatic Regulator of Cutaneous Inflammation and Barrier Function in Mouse SkinSemantic proximity Read

Selective deletion of PPARβ/δ in fibroblasts causes dermal fibrosis by attenuated LRG1 expressionSemantic proximity Read

Activation of PPARbeta/delta causes a psoriasis-like skin disease in vivo.Semantic proximity Read

Analysis of intracellular communication reveals consistent gene changes associated with early-stage acne skinSemantic proximity Read

PPAR-γ Agonists and Their Role in Primary Cicatricial AlopeciaSemantic proximity Read

Inflammasome Activation in Cutaneous Squamous Cell CarcinomaSemantic proximity Read

Single-cell transcriptomics reveals aberrant skin-resident cell populations and identifies fibroblasts as a determinant in rosaceaSemantic proximity Read

Transcriptome Analysis of Pterygium and Pinguecula Reveals Evidence of Genomic Instability Associated with Chronic InflammationSemantic proximity Read

Rosiglitazone alleviates the persistent fibrotic phenotype of lesional skin scleroderma fibroblasts.Semantic proximity Read

Nuclear hormone receptors and mouse skin homeostasis: implication of PPARbeta.Semantic proximity Read

Effect of isolated keratin 3 knockdown on gene expression of primary limbal epithelial cells without and with inflammatory stimuliSemantic proximity Read

Transcriptome Analysis Reveals Intrinsic Proinflammatory Signaling in Healthy African American SkinSemantic proximity Read