Article
The cannabinoid receptor CB2 exerts antifibrotic effects in experimental dermal fibrosis.
Arthritis and rheumatism - 1 Apr 2009
Akhmetshina Alfiya, Dees Clara, Busch Nicole, Beer Jürgen, Sarter Kerstin, Zwerina Jochen, Zimmer Andreas, Distler Oliver, Schett Georg, Distler Jörg H W
Abstract excerpt
OBJECTIVE: The cannabinoid receptor CB2 is predominantly expressed in non-neuronal tissue and exerts potent immunomodulatory effects. This study was undertaken to evaluate the role of CB2 in the pathogenesis of dermal fibrosis. METHODS: Mice deficient in CB2 (CB2(-/-) mice) and their wild-type li...
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