Article
The prevalence of germ-line TP53 mutations in women diagnosed with breast cancer before age 30.
Familial cancer - 1 Jan 2009
Ginsburg Ophira M, Akbari Mohammad R, Aziz Zeba, Young Robert, Lynch Henry, Ghadirian Parviz, Robidoux Andre, Londono Julian, Vasquez Gonzalo, Gomes Magda, Costa Mauricio Magalhaes, Dimitrakakis Constantine, Gutierrez Gustavo, Pilarski Robert, Royer Robert, Narod Steven A
Abstract excerpt
Germ-line mutations in the TP53 gene are rare, but predispose women to a range of cancer types, including early-onset breast cancer. Breast cancers in women from families with the Li-Fraumeni syndrome often occur before age 30. The prevalence of deleterious TP53 mutations in unselected women with early-onset breast cancer is not precisely known. If mutations were found to be sufficiently common, it might be...
Topics
- Adult
- Age of Onset
- Breast Neoplasms
- DNA Mutational Analysis
- Female
- Genes, p53
- Genetic Predisposition to Disease
- Germ-Line Mutation
- Humans
- Li-Fraumeni Syndrome
- Pedigree
- Prevalence