Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Routine TP53 testing for breast cancer under age 30: ready for prime time?

Familial cancer - 1 Dec 2012

McCuaig Jeanna M, Armel Susan R, Novokmet Ana, Ginsburg Ophira M, Demsky Rochelle, Narod Steven A, Malkin David

Abstract excerpt

It is well known that early-onset breast cancer may be due to an inherited predisposition. When evaluating women diagnosed with breast cancer under age 30, two important syndromes are typically considered: Hereditary Breast and Ovarian Cancer Syndrome and Li-Fraumeni syndrome. Many women are offered genetic testing for mutations in the BRCA1 and BRCA2 genes; however, few are offered genetic testing for mutations...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to BRCA1 Protein
Share to BRCA2 Protein
Share to Breast Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Diagnostic Tests, Routine

Share to Pedigree

Share to Prognosis

Share to Tumor Suppressor Protein p53

Share to Young Adult

Source

Identifiers

PMID: 22851211
DOI: 10.1007/s10689-012-9557-z

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Routine TP53 testing for breast cancer under age 30: ready for prime time?PMID 22851211Read ↗

The prevalence of germ-line TP53 mutations in women diagnosed with breast cancer before age 30.Semantic proximity Read ↗

BRCA1, BRCA2 and TP53 mutations in very early-onset breast cancer with associated risks to relatives.Semantic proximity Read ↗

Differences in TP53 Mutation Carrier Phenotypes Emerge From Panel-Based Testing.Semantic proximity Read ↗

Apparently "BRCA-related" breast and ovarian cancer patient with germline TP53 mutation.Semantic proximity Read ↗

The benefit and burden of cancer screening in Li-Fraumeni syndrome: a case report.Semantic proximity Read ↗

Population-based estimate of the contribution of TP53 mutations to subgroups of early-onset breast cancer: Australian Breast Cancer Family Study.Semantic proximity Read ↗

Prediction of pathogenic mutations in patients with early-onset breast cancer by family history.Semantic proximity Read ↗

Li-Fraumeni syndrome: cancer risk assessment and clinical management.Semantic proximity Read ↗

Results from London Regional Clinical Genetics services over a 5-year period on germline TP53 testing in women diagnosed with breast cancer at <30 years.Semantic proximity Read ↗

Early onset HER2-positive breast cancer is associated with germline TP53 mutations.Semantic proximity Read ↗

The role of TP53 pathogenic variants in early-onset HER2-positive breast cancer.Semantic proximity Read ↗

Genetic testing in a cohort of young patients with HER2-amplified breast cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.