Article
Genetic variants in germline TP53 and MDM2 SNP309 are not associated with early onset colorectal cancer.
Journal of surgical oncology - 1 Jun 2008
Khan Sajid A, Idrees Kamran, Forslund Ann, Zeng Zhaoshi, Rosenberg Shoshana, Pincas Hanna, Barany Francis, Offit Kenneth, Laquaglia Michael P, Paty Philip B
Abstract excerpt
BACKGROUND AND OBJECTIVES: Colorectal cancer (CRC) arising in patients under age 30 is a rare disease, and few cases have been reported within Li-Fraumeni kindreds. To determine how often alterations in the p53 pathway genes contribute to disease susceptibility, we have evaluated patients with early onset CRC for the presence of germline variants in the p53 gene and MDM2 SNP309. METHODS: Thirty-five patients with...
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