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Article

Prediction of pathogenic mutations in patients with early-onset breast cancer by family history.

Lancet (London, England) - 29 Mar 2003

Lalloo Fiona, Varley Jennifer, Ellis David, Moran Anthony, O'Dair Lindsay, Pharoah Paul, Evans D Gareth R

Abstract excerpt

We aimed to assess frequency and penetrance of BRCA1, BRCA2,and TP53 mutations in women diagnosed with breast cancer aged 30 years or younger, and then correlate this frequency with family history. 17 of 36 familial cases had a BRCA1, BRCA2, or TP53 mutation, compared with three of 63 non-familial cases. The calculated population frequency of TP53 mutations was one in 5000, substantially greater than previous...

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Identifiers

PMID: 12672316
DOI: 10.1016/S0140-6736(03)12856-5

Genes

BRCA1
BRCA2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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