Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The role of TP53 pathogenic variants in early-onset HER2-positive breast cancer.

Familial cancer - 1 Jul 2021

Escudeiro Carla, Pinto Carla, Vieira Joana, Peixoto Ana, Pinto Pedro, Pinheiro Manuela, Santos Catarina, Guerra Joana, Lisboa Susana, Santos Rui, Silva João, Leal Conceição, Coimbra Nuno, Lopes Paula, Ferreira Marco, Sousa Ana B, Teixeira Manuel R

Abstract excerpt

Breast cancer is the most frequent event in Li-Fraumeni syndrome associated with germline TP53 variants. Some studies have shown that breast cancers in women with Li-Fraumeni syndrome are commonly HER2-positive, suggesting that HER2 amplification or over-expression in a young woman may be a useful criterion to test for germline variants in the TP53 gene. We assessed the prevalence of germline TP53 variants by...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Age Factors
Share to Carcinoma, Ductal, Breast

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Amplification

Share to Genes, erbB-2

Share to Genes, p53

Share to Germ-Line Mutation

Share to In Situ Hybridization, Fluorescence

Share to Li-Fraumeni Syndrome

Source

Identifiers

PMID: 33051812
DOI: 10.1007/s10689-020-00212-2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The role of TP53 pathogenic variants in early-onset HER2-positive breast cancer.PMID 33051812Read ↗

Early onset HER2-positive breast cancer is associated with germline TP53 mutations.Semantic proximity Read ↗

Suggested application of HER2+ breast tumor phenotype for germline TP53 variant classification within ACMG/AMP guidelines.Semantic proximity Read ↗

Case series of Li-Fraumeni syndrome: carcinogenic mechanisms in breast cancer with TP53 pathogenic variant carriers.Semantic proximity Read ↗

Apparently "BRCA-related" breast and ovarian cancer patient with germline TP53 mutation.Semantic proximity Read ↗

Current review of TP53 pathogenic germline variants in breast cancer patients outside Li-Fraumeni syndromeSemantic proximity Read ↗

Genotypic and phenotypic characteristics of germline TP53 variant carriers: experience from two cancer genetic counseling units.Semantic proximity Read ↗

Population-based estimate of the contribution of TP53 mutations to subgroups of early-onset breast cancer: Australian Breast Cancer Family Study.Semantic proximity Read ↗

Germline TP53 pathogenic variants and breast cancer: A narrative review.Semantic proximity Read ↗

Comparable frequency of BRCA1, BRCA2 and TP53 germline mutations in a multi-ethnic Asian cohort suggests TP53 screening should be offered together with BRCA1/2 screening to early-onset breast cancer patients.Semantic proximity Read ↗

Prediction of pathogenic mutations in patients with early-onset breast cancer by family history.Semantic proximity Read ↗

Deciphering dual clinical entities associated with TP53 pathogenic variants: Insights from 53,085 HBOC panel analyses in French laboratories.Semantic proximity Read ↗

Routine TP53 testing for breast cancer under age 30: ready for prime time?Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.