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Population-based estimate of the contribution of TP53 mutations to subgroups of early-onset breast cancer: Australian Breast Cancer Family Study.

Cancer research - 15 Jun 2010

Mouchawar Judy, Korch Christopher, Byers Tim, Pitts Todd M, Li Efang, McCredie Margaret R E, Giles Graham G, Hopper John L, Southey Melissa C

Abstract excerpt

Although germline TP53 mutations have been identified in women with breast cancer from families meeting Li-Fraumeni criteria, their contribution to breast cancer per se is not well known, but is thought to be minimal. We aimed to determine the prevalence of germline TP53 mutations in subgroups of early-onset breast cancer. Germline TP53 mutation status was assessed by DNA sequencing, screening for heterozygous...

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Identifiers

PMID: 20501846
DOI: 10.1158/0008-5472.CAN-09-0851
PMCID: PMC3228832

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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