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Polymorphisms in DNA repair genes and breast cancer risk in Russian population: a case-control study.

Clinical and experimental medicine - 1 Feb 2016

Shadrina Alexandra S, Ermolenko Natalia A, Boyarskikh Uljana A, Sinkina Tatiana V, Lazarev Alexandr F, Petrova Valentina D, Filipenko Maxim L

Abstract excerpt

Genetic variation in DNA repair genes can alter an individual's capacity to repair damaged DNA and influence the risk of cancer. We tested seven polymorphisms in DNA repair genes XRCC1, ERCC2, XRCC3, XRCC2, EXOI and TP53 for a possible association with breast cancer risk in a sample of 672 case and 672 control Russian women. An association was observed for allele A of the polymorphism XRCC1 (R399Q) rs25487...

Topics

Adult
Aged
Aged, 80 and over
Breast Neoplasms
Case-Control Studies
DNA Repair
DNA-Binding Proteins
Female

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genetic Association Studies

Genetic Predisposition to Disease

Humans

Middle Aged

Polymorphism, Single Nucleotide

Russia

White People

X-ray Repair Cross Complementing Protein 1

Xeroderma Pigmentosum Group D Protein

Young Adult

Source

Identifiers

PMID: 25537147
DOI: 10.1007/s10238-014-0329-y

Genes

ERCC2
XRCC1
XRCC2
XRCC3

Variants

rs1799793
rs25487

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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