Article
A novel leukocyte adhesion deficiency caused by expressed but nonfunctional beta2 integrins Mac-1 and LFA-1.
The Journal of clinical investigation - 1 Jan 1999
Hogg N, Stewart M P, Scarth S L, Newton R, Shaw J M, Law S K, Klein N
Abstract excerpt
In the leukocyte adhesion deficiency (LAD)-1 syndrome, there is diminished expression of beta2(CD18) integrins. This is caused by lesions in the beta2-subunit gene and gives rise to recurrent bacterial infections, impaired pus formation, and poor wound healing. We describe a patient with clinical...
Topics
- Adolescent
- CD18 Antigens
- Cell Adhesion Molecules
- Cell Line
- DNA Mutational Analysis
- Fibronectins
- Flow Cytometry
- Gene Expression
- Humans
- Leukocyte-Adhesion Deficiency Syndrome
- Lymphocyte Function-Associated Antigen-1
- Macrophage-1 Antigen
- Manganese
- Mutation
- Neutrophils