Article
Phenotypic and functional characteristics of HIV-specific CD8 T cells and gag sequence variability after autologous dendritic cells based therapeutic vaccine.
Vaccine - 19 Oct 2009
López Anna, van der Lubbe Nils, Sánchez-Palomino Sonsoles, Arnedo Mireia, Nomdedeu Meritxell, Castro Pedro, Guilà Meritxell, Maleno Maria J, García Felipe, Gallart Teresa, Gatell José M, Plana Montserrat
Abstract excerpt
A decrease in HIV-1 specific CD8 T-cell responses associated with a partial control of viral replication occurred in 12 HIV-1-infected patients during autologous dendritic cells vaccination. HIV CD8 T cells were detected in 6/10 patients during immunizations, increasing after HAART discontinuation in 3 of them. Tet+ CD8 cells mainly had an effector phenotype (CD45RA-/+ CCR7- and CD28- and Perf+/-) and maintained...
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