Article
Resistance mutations and CTL epitopes in archived HIV-1 DNA of patients on antiviral treatment: toward a new concept of vaccine.
PloS one - 1 Jan 2013
Papuchon Jennifer, Pinson Patricia, Lazaro Estibaliz, Reigadas Sandrine, Guidicelli Gwendaline, Taupin Jean-Luc, Neau Didier, Fleury Hervé
Abstract excerpt
Eleven patients responding successfully to first-line antiretroviral therapy (ART) were investigated for proviral drug resistance mutations (DRMs) in RT by ultra-deep pyrosequencing (UDPS). After molecular typing of the class I alleles A and B, the CTL epitopes in the Gag, Nef and Pol regions of the provirus were sequenced and compared to the reference HXB2 HIV-1 epitopes. They were then matched with the HLA...
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