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Article

ART-Treated Patients Exhibit an Adaptive Immune Response against the HFVAC Peptides, a Potential HIV-1 Therapeutic Vaccine (Provir/Latitude45 Study).

Viruses - 5 Nov 2020

Fleury Hervé, Caldato Sabrina, Recordon-Pinson Patricia, Thebault Patricia, Guidicelli Gwenda-Line, Hessamfar Mojgan, Morlat Philippe, Bonnet Fabrice, Visentin Jonathan

Abstract excerpt

We proposed a new HIV-1 therapeutic vaccine based on conserved cytotoxic T lymphocyte (CTL) epitopes of archived HIV-1 DNA according to their affinity to the dominant HLA-A and -B alleles of the population investigated. Our proposal (Hla Fitted VAC, HFVAC) was composed of 15 peptides originating from the RT, gag and nef parts of proviral DNA. Our aim was to investigate baseline immune reactivity to the vaccine in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 33167335
DOI: 10.3390/v12111256
PMCID: PMC7694376

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