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Emerging role and mechanism of HACE1 in the pathogenesis of neurodegenerative diseases: A promising target

15 Feb 2024

Abstract excerpt

HACE1 is a member of the HECT domain-containing E3 ligases with 909 amino acid residues, containing N-terminal ankyrin-repeats (ANK) and C-terminal HECT domain. Previously, it was shown that HACE1 is inactive in human tumors and plays a crucial role in the initiation, progression, and invasion of malignant tumors. Recent studies indicated that HACE1 might be closely involved in neurodegenerative diseases such as...

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PMID: 38364733
DOI: 10.1016/j.biopha.2024.116204

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