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Article

Sex-dependent effect of BAG1 in ameliorating motor deficits of Huntington disease transgenic mice.

The Journal of biological chemistry - 6 Jun 2008

Orr Adam L, Huang Shanshan, Roberts Meredith A, Reed John C, Li Shihua, Li Xiao-Jiang

Abstract excerpt

The pathogenesis of Huntington disease (HD) is attributed to the misfolding of huntingtin (htt) caused by an expanded polyglutamine (polyQ) domain. Considerable effort has been devoted to identifying molecules that can prevent or reduce htt misfolding and the associated neuropathology. Although overexpression of chaperones is known to reduce htt cytotoxicity in cellular models, only modest protection is seen with...

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Source

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Identifiers

PMID: 18400759
DOI: 10.1074/jbc.M710606200
PMCID: PMC2414304

Genes

BAG1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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