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Article

CRISPR analysis of bacteriophage-insensitive mutants (BIMs) of industrial Streptococcus thermophilus--implications for starter design.

Journal of applied microbiology - 1 Mar 2010

Mills S, Griffin C, Coffey A, Meijer W C, Hafkamp B, Ross R P

Abstract excerpt

AIMS: An efficient approach for generation of bacteriophage-insensitive mutants (BIMs) of Streptococcus thermophilus starters was described in our laboratory [Mills et al. (2007) J Microbiol Methods70, 159-164]. The aim of this study was to analyse the phage resistance mechanism responsible for BIM formation. METHODS AND RESULTS: Three clustered regularly interspaced short palindromic repeat (CRISPR) regions have...

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PMID: 19709335
DOI: 10.1111/j.1365-2672.2009.04486.x

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