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Acquired CRISPR spacers and rhamnose-glucose polysaccharide defects confer resistance to <i>Streptococcus mutans</i> phage ɸAPCM01

2025-05-07

Abstract excerpt

Streptococcus mutans is a major cause of dental caries worldwide. Targeted therapeutic strategies to eradicate S. mutans include oral phage rinses. In this study, we investigated how phage resistance develops in S. mutans . As a model phage, we used ɸAPCM01, which is known to infect a serotype e strain. We isolated and sequenced the genomes of 15 spontaneous resistant mutants and found that 10 had acquired novel...

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Literature Corpus work
8040ebcb-8d6d-53ab-b00f-ce2942c5f66d
DOI
10.1101/2025.05.05.652303
Open publication

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Acquired CRISPR spacers and rhamnose-glucose polysaccharide defects confer resistance to <i>Streptococcus mutans</i> phage ɸAPCM01DOI 10.1101/2025.05.05.652303
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