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The p53 Arg72Pro and MDM2 -309 polymorphisms and risk of breast cancer in the nurses' health studies.

Cancer causes & control : CCC - 1 Aug 2007

Cox David G, Deer Dwayne, Guo Qun, Tworoger Shelley S, Hankinson Susan E, Hunter David J, De Vivo Immaculata

Abstract excerpt

Candidate gene association studies to detect breast cancer susceptibility loci have yielded few positive associations. Therefore, it is more likely that variants in many genes along related biological pathways combine to influence breast cancer risk. A strong candidate pathway is that of p53-mediated cell-cycle control, DNA repair, and apoptosis. The two major proteins along this pathway are p53 and its negative...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Intracellular Signaling Peptides and Proteins

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Share to Polymorphism, Single Nucleotide

Share to Proto-Oncogene Proteins c-mdm2

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Share to Tumor Suppressor p53-Binding Protein 1

Source

Identifiers

PMID: 17387621
DOI: 10.1007/s10552-007-9004-x

Genes

MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The p53 Arg72Pro and MDM2 -309 polymorphisms and risk of breast cancer in the nurses' health studies.PMID 17387621Read ↗

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