Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Akt-Fas to Quell Aberrant T Cell Differentiation and Apoptosis in Covid-19

21 Dec 2020

Abstract excerpt

Aberrant T cell differentiation and lymphopenia are hallmarks of severe COVID-19 disease. Since T cells must race to cull infected cells, they are quick to differentiate and achieve cytotoxic function. With this responsiveness, comes hastened apoptosis, due to a coupled mechanism of death and differentiation in both CD4+ and CD8+ lymphocytesviaCD95 (Fas) and serine-threonine kinase (Akt). T cell lymphopenia in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Immunotherapy and Biomarkers
Share to COVID-19 Clinical Research Studies
Share to SARS-CoV-2 and COVID-19 Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 33408715
DOI: 10.3389/fimmu.2020.600405

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Akt-Fas to Quell Aberrant T Cell Differentiation and Apoptosis in Covid-19PMID 33408715Read ↗

T cell apoptosis characterizes severe Covid-19 diseaseSemantic proximity Read ↗

Generation of Cytotoxic T cells and Dysfunctional CD8 T Cells in Severe COVID19 PatientsSemantic proximity Read ↗

Expansion of Cytotoxic CD4+ T cells in the lungs in severe COVID-19Semantic proximity Read ↗

Programmed cell death: the pathways to severe COVID-19?Semantic proximity Read ↗

COVID-19 pneumonia: CD8+ T and NK cells are decreased in number but compensatory increased in cytotoxic potentialSemantic proximity Read ↗

MATURE T LYMPHOCYTE APOPTOSIS—Immune Regulation in a Dynamic and Unpredictable Antigenic EnvironmentSemantic proximity Read ↗

Expansion of Cytotoxic CD4+ T Cells in the Lungs in Severe COVID-19Semantic proximity Read ↗

Natural Killer Cell Dysfunction and Its Role in COVID-19Semantic proximity Read ↗

Clearance of dead cells: mechanisms, immune responses and implication in the development of diseasesSemantic proximity Read ↗

Discovery of T-Cell Infection and Apoptosis by Middle East Respiratory Syndrome CoronavirusSemantic proximity Read ↗

Apoptosis in the Homeostasis of the Immune System and in Human Immune Mediated DiseasesSemantic proximity Read ↗

Cell-in-cell: an emerging player in COVID-19 and immune disordersSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.