Article
Mutations in a gene encoding a midbody kelch protein in familial and sporadic classical Hodgkin lymphoma lead to binucleated cells.
Proceedings of the National Academy of Sciences of the United States of America - 1 Sept 2009
Salipante Stephen J, Mealiffe Matthew E, Wechsler Jeremy, Krem Maxwell M, Liu Yajuan, Namkoong Shinae, Bhagat Govind, Kirchhoff Tomas, Offit Kenneth, Lynch Henry, Wiernik Peter H, Roshal Mikhail, McMaster Mary Lou, Tucker Margaret, Fromm Jonathan R, Goldin Lynn R, Horwitz Marshall S
Abstract excerpt
Classical Hodgkin lymphoma (cHL) is a malignancy of B-cell origin in which the neoplastic cells, known as "Reed-Sternberg" (RS) cells, are characteristically binucleated. Here we describe a family where multiple individuals developing cHL have inherited a reciprocal translocation between chromosomes 2 and 3. The translocation disrupts KLHDC8B, an uncharacterized gene from a region (3p21.31) previously implicated...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.