Article

Whole-genome Sequencing of Reed-sternberg Cells Identifies Outcome Determinants in Hodgkin Lymphoma

2026-06-28

Abstract excerpt

<title>Abstract</title> <p>Classical Hodgkin lymphoma (cHL) is a B-cell-derived malignancy characterized by rare Hodgkin and Reed–Sternberg (HRS) cells within an extensive inflammatory microenvironment. Although most patients achieve durable remission with first-line therapy, a subset relapse or experience disease progression. We performed whole-genome sequencing (WGS) of purified HRS-cell pools isolated from dia...

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Literature Corpus work: bfa62f70-d1e5-5664-96fc-be3eeb2c5217
DOI: 10.21203/rs.3.rs-9880329/v1

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