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Article

β-arrestin-2 regulation of the cAMP response element binding protein.

Biochemistry - 12 Jul 2011

Manson Mary E, Corey Deborah A, Rymut Sharon M, Kelley Thomas J

Abstract excerpt

Previous work demonstrated that cystic fibrosis (CF) cells exhibit an increase in cAMP-mediated signaling as a characteristic response to lost CFTR function. Evidence for increased cAMP-mediated signaling in CF included increased phosphorylation of the cAMP response element binding protein (CREB) and elevated β-arrestin-2 (βarr2) expression. However, subsequent studies reveal that CREB activation in CF cells is...

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Source

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Identifiers

PMID: 21644508
DOI: 10.1021/bi200015h
PMCID: PMC3133940

Genes

CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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