Emi1 maintains genomic integrity during zebrafish embryogenesis and cooperates with p53 in tumor suppression.

doi:10.1128/MCB.00558-09

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Emi1 maintains genomic integrity during zebrafish embryogenesis and cooperates with p53 in tumor suppression.

Molecular and cellular biology - 1 Nov 2009

Rhodes Jennifer, Amsterdam Adam, Sanda Takaomi, Moreau Lisa A, McKenna Keith, Heinrichs Stefan, Ganem Neil J, Ho Karen W, Neuberg Donna S, Johnston Adam, Ahn Yebin, Kutok Jeffery L, Hromas Robert, Wray Justin, Lee Charles, Murphy Carly, Radtke Ina, Downing James R, Fleming Mark D, MacConaill Laura E, Amatruda James F, Gutierrez Alejandro, Galinsky Ilene, Stone Richard M, Ross Eric A, Pellman David S, Kanki John P, Look A Thomas

Abstract excerpt

A growing body of evidence indicates that early mitotic inhibitor 1 (Emi1) is essential for genomic stability, but how this function relates to embryonic development and cancer pathogenesis remains unclear. We have identified a zebrafish mutant line in which deficient emi1 gene expression results in multilineage hematopoietic defects and widespread developmental defects that are p53 independent. Cell cycle...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Cycle

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Size

Share to Embryo, Nonmammalian

Share to Embryonic Development

Share to Hematopoiesis

Share to Myeloid Cells

Share to Zebrafish

Share to Zebrafish Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 19704007
DOI: 10.1128/MCB.00558-09
PMCID: PMC2772726

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Emi1 maintains genomic integrity during zebrafish embryogenesis and cooperates with p53 in tumor suppression.PMID 19704007Read ↗

Rereplication in emi1-deficient zebrafish embryos occurs through a Cdh1-mediated pathway.Semantic proximity Read ↗

Ewing Sarcoma Protein Ewsr1 Maintains Mitotic Integrity and Proneural Cell Survival in the Zebrafish EmbryoSemantic proximity Read ↗

A zebrafish bmyb mutation causes genome instability and increased cancer susceptibility.Semantic proximity Read ↗

Antagonistic interactions safeguard mitotic propagation of genetic and epigenetic information in zebrafish.Semantic proximity Read ↗

Mutation in mouse hei10, an e3 ubiquitin ligase, disrupts meiotic crossing over.Semantic proximity Read ↗

MCRS1 is essential for epiblast development during early mouse embryogenesis.Semantic proximity Read ↗

Impaired mitotic progression and preimplantation lethality in mice lacking OMCG1, a new evolutionarily conserved nuclear protein.Semantic proximity Read ↗

Mutation of zebrafish caf-1b results in S phase arrest, defective differentiation, and p53-mediated apoptosis during organogenesis.Semantic proximity Read ↗

Mutation of NIMA-related kinase 1 (NEK1) leads to chromosome instability.Semantic proximity Read ↗

Genetic ablation of <i>Cyclin D1</i> abrogates genesis of rhabdoid tumors resulting from <i>Ini1</i> lossSemantic proximity Read ↗

DNA hypomethylation induces a DNA replication-associated cell cycle arrest to block hepatic outgrowth in uhrf1 mutant zebrafish embryosSemantic proximity Read ↗

Loss of cell cycle control renders cells nonresponsive to local extrinsic differentiation cuesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.