Article
Mrd1p is required for release of base-paired U3 snoRNA within the preribosomal complex.
Molecular and cellular biology - 1 Nov 2009
Lundkvist Pär, Jupiter Sara, Segerstolpe Asa, Osheim Yvonne N, Beyer Ann L, Wieslander Lars
Abstract excerpt
In eukaryotes, ribosomes are made from precursor rRNA (pre-rRNA) and ribosomal proteins in a maturation process that requires a large number of snoRNPs and processing factors. A fundamental problem is how the coordinated and productive folding of the pre-rRNA and assembly of successive pre-rRNA-protein complexes is achieved cotranscriptionally. The conserved protein Mrd1p, which contains five RNA binding domains...
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