Article
The roles of S1 RNA-binding domains in Rrp5's interactions with pre-rRNA.
RNA (New York, N.Y.) - 1 Mar 2011
Young Crystal L, Karbstein Katrin
Abstract excerpt
RNA-binding proteins mediate the function of all RNAs. Since few distinct RNA-binding domains (RBDs) exist, with most RBDs contacting only a few nucleotides, RNA-binding proteins often combine multiple RNA-binding motifs to achieve a higher affinity and selectivity for their targets. Rrp5, a ribosome assembly factor essential for both 40S and 60S ribosome maturation, is an extreme example as it contains 12 tandem...
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