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Article

Utp14 Recruits and Activates the RNA Helicase Dhr1 To Undock U3 snoRNA from the Preribosome.

Molecular and cellular biology - 4 Jan 2016

Zhu Jieyi, Liu Xin, Anjos Margarida, Correll Carl C, Johnson Arlen W

Abstract excerpt

In eukaryotic ribosome biogenesis, U3 snoRNA base pairs with the pre-rRNA to promote its processing. However, U3 must be removed to allow folding of the central pseudoknot, a key feature of the small subunit. Previously, we showed that the DEAH/RHA RNA helicase Dhr1 dislodges U3 from the pre-rRNA. DHR1 can be linked to UTP14, encoding an essential protein of the preribosome, through genetic interactions with the...

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Identifiers

PMID: 26729466
DOI: 10.1128/MCB.00773-15
PMCID: PMC4810474

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Utp14 Recruits and Activates the RNA Helicase Dhr1 To Undock U3 snoRNA from the Preribosome.PMID 26729466Read ↗

Utp14 interaction with the small subunit processome.Semantic proximity Read ↗

Bud23 promotes the final disassembly of the small subunit Processome in Saccharomyces cerevisiae.Semantic proximity Read ↗

The rRNA methyltransferase Bud23 shows functional interaction with components of the SSU processome and RNase MRP.Semantic proximity Read ↗

Physical and functional interaction between the methyltransferase Bud23 and the essential DEAH-box RNA helicase Ecm16.Semantic proximity Read ↗

Mammalian DEAD box protein Ddx51 acts in 3' end maturation of 28S rRNA by promoting the release of U8 snoRNA.Semantic proximity Read ↗

hUTP24 is essential for processing of the human rRNA precursor at site A1, but not at site A0.Semantic proximity Read ↗

Mrd1p is required for release of base-paired U3 snoRNA within the preribosomal complex.Semantic proximity Read ↗

The nucleolar protein Nop19p interacts preferentially with Utp25p and Dhr2p and is essential for the production of the 40S ribosomal subunit in Saccharomyces cerevisiae.Semantic proximity Read ↗

The PINc domain protein Utp24, a putative nuclease, is required for the early cleavage steps in 18S rRNA maturation.Semantic proximity Read ↗

Structure of the DEAH/RHA ATPase Prp43p bound to RNA implicates a pair of hairpins and motif Va in translocation along RNA.Semantic proximity Read ↗

The DEAD box protein Mrh4 functions in the assembly of the mitochondrial large ribosomal subunit.Semantic proximity Read ↗

Genetic interactions show the importance of rRNA modification machinery for the role of Rps15p during ribosome biogenesis in S. cerevisiae.Semantic proximity Read ↗

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