Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mrd1p binds to pre-rRNA early during transcription independent of U3 snoRNA and is required for compaction of the pre-rRNA into small subunit processomes.

Nucleic acids research - 1 Aug 2008

Segerstolpe Asa, Lundkvist Pär, Osheim Yvonne N, Beyer Ann L, Wieslander Lars

Abstract excerpt

In Saccharomyces cerevisiae, synthesis of the small ribosomal subunit requires assembly of the 35S pre-rRNA into a 90S preribosomal complex. SnoRNAs, including U3 snoRNA, and many trans-acting proteins are required for the ordered assembly and function of the 90S preribosomal complex. Here, we show that the conserved protein Mrd1p binds to the pre-rRNA early during transcription and is required for compaction of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Nucleolus
Share to Phosphoproteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Ribonucleoproteins

Share to Ribosomal Proteins

Share to RNA Precursors

Share to RNA Processing, Post-Transcriptional

Share to RNA, Ribosomal

Share to RNA, Small Nucleolar

Source

Open in PubMed Open full text

Identifiers

PMID: 18586827
DOI: 10.1093/nar/gkn384
PMCID: PMC2490760

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mrd1p binds to pre-rRNA early during transcription independent of U3 snoRNA and is required for compaction of the pre-rRNA into small subunit processomes.PMID 18586827Read ↗

Mrd1p is required for release of base-paired U3 snoRNA within the preribosomal complex.Semantic proximity Read ↗

Linker 2 of the eukaryotic pre-ribosomal processing factor Mrd1p is an essential interdomain functionally coupled to upstream RNA Binding Domain 2 (RBD2).Semantic proximity Read ↗

Nop6, a component of 90S pre-ribosomal particles, is required for 40S ribosomal subunit biogenesis in Saccharomyces cerevisiae.Semantic proximity Read ↗

Association of snR190 snoRNA chaperone with early pre-60S particles is regulated by the RNA helicase Dbp7 in yeast.Semantic proximity Read ↗

Genetic interactions show the importance of rRNA modification machinery for the role of Rps15p during ribosome biogenesis in S. cerevisiae.Semantic proximity Read ↗

Utp14 interaction with the small subunit processome.Semantic proximity Read ↗

An essential GTPase promotes assembly of preribosomal RNA processing complexes.Semantic proximity Read ↗

The Saccharomyces cerevisiae small GTPase, Gsp1p/Ran, is involved in 3' processing of 7S-to-5.8S rRNA and in degradation of the excised 5'-A0 fragment of 35S pre-rRNA, both of which are carried out by the exosome.Semantic proximity Read ↗

rRNA maturation in yeast cells depleted of large ribosomal subunit proteins.Semantic proximity Read ↗

Yvh1 is required for a late maturation step in the 60S biogenesis pathway.Semantic proximity Read ↗

Bud23 promotes the final disassembly of the small subunit Processome in Saccharomyces cerevisiae.Semantic proximity Read ↗

Rrs1p, a ribosomal protein L11-binding protein, is required for nuclear export of the 60S pre-ribosomal subunit in Saccharomyces cerevisiae.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.