Article
Oligomerization of membrane-bound Bcl-2 is involved in its pore formation induced by tBid.
Apoptosis : an international journal on programmed cell death - 1 Oct 2009
Peng Jun, Ding Jingzhen, Tan Chibing, Baggenstoss Bruce, Zhang Zhi, Lapolla Suzanne M, Lin Jialing
Abstract excerpt
Both pro-apoptotic Bax and anti-apoptotic Bcl-2 are structurally homologous to the pore-forming domain of bacterial toxins. Bax proteins oligomerize in the mitochondrial outer membranes forming pores that release cytochrome c from the mitochondrial intermembrane space. Bcl-2 proteins also form pores that, however, are much smaller than the Bax pore. It is unknown whether Bcl-2 forms monomeric or oligomeric pores....
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