Article
Active Bax and Bak are functional holins.
Genes & development - 1 Nov 2011
Pang Xiaming, Moussa Samir H, Targy Natalie M, Bose Jeffrey L, George Nicholas M, Gries Casey, Lopez Hernando, Zhang Liqiang, Bayles Kenneth W, Young Ry, Luo Xu
Abstract excerpt
The mechanism of Bax/Bak-dependent mitochondrial outer membrane permeabilization (MOMP), a central apoptotic event primarily controlled by the Bcl-2 family proteins, remains not well understood. Here, we express active Bax/Bak in bacteria, the putative origin of mitochondria, and examine their functional similarities to the λ bacteriophage (λ) holin. As critical effectors for bacterial lysis, holin oligomers form...
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