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Article

The mitochondrial gateway to cell death

18 Apr 2008

Abstract excerpt

Mitochondria play a key role in death signaling. The intermembrane space of these organelles contains a number of proteins which promote cell death once they are redistributed to the cytosol. The formation of pores in the outer membrane of mitochondria defines a gateway through which the apoptogenic proteins pass during death signaling. Interactions between pro-apoptotic and pro-survival members of the Bcl-2...

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Share to Autophagy in Disease and Therapy
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Share to Mitochondrial Function and Pathology

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PMID: 18425780
DOI: 10.1002/iub.44

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