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Article

Leukemia-associated mutations within the NOTCH1 heterodimerization domain fall into at least two distinct mechanistic classes.

Molecular and cellular biology - 1 Jun 2006

Malecki Michael J, Sanchez-Irizarry Cheryll, Mitchell Jennifer L, Histen Gavin, Xu Mina L, Aster Jon C, Blacklow Stephen C

Abstract excerpt

The NOTCH1 receptor is cleaved within its extracellular domain by furin during its maturation, yielding two subunits that are held together noncovalently by a juxtamembrane heterodimerization (HD) domain. Normal NOTCH1 signaling is initiated by the binding of ligand to the extracellular subunit, which renders the transmembrane subunit susceptible to two successive cleavages within and C terminal to the...

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Share to Dimerization
Share to Leukemia-Lymphoma, Adult T-Cell

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Protein Structure, Quaternary

Share to Protein Structure, Tertiary

Share to Receptor, Notch1

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Source

Open in PubMed Open full text

Identifiers

PMID: 16738328
DOI: 10.1128/MCB.01655-05
PMCID: PMC1489116

Genes

NOTCH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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