Article
Suboptimal recognition of a T cell epitope of the major dog allergen Can f 1 by human T cells.
Molecular immunology - 1 Oct 2009
Juntunen Riikka, Liukko Aino, Taivainen Antti, Närvänen Ale, Durand Guillaume, Kauppinen Anu, Nieminen Anssi, Rytkönen-Nissinen Marja, Saarelainen Soili, Maillère Bernard, Virtanen Tuomas, Kinnunen Tuure
Abstract excerpt
We have previously proposed that mammalian lipocalin allergens are recognized suboptimally by the human immune system due to their homology with endogenous lipocalins. Here, we have characterized in detail the human T cell recognition of one of the previously identified T cell epitopes of the major dog allergen Can f 1, contained in peptide p105-120. A panel of peptide analogues (altered peptide ligands, APLs) of...
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