Article
"Allergen engineering": variants of the timothy grass pollen allergen Phl p 5b with reduced IgE-binding capacity but conserved T cell reactivity.
Journal of immunology (Baltimore, Md. : 1950) - 15 Feb 1999
Schramm G, Kahlert H, Suck R, Weber B, Stüwe H T, Müller W D, Bufe A, Becker W M, Schlaak M W, Jäger L, Cromwell O, Fiebig H
Abstract excerpt
One problem of conventional allergen-specific immunotherapy is the risk of anaphylactic reactions. A new approach to make immunotherapy safer and more efficient might be the application of engineered allergens with reduced IgE-binding capacity but retained T cell reactivity. Using overlapping dodeca-peptides, the dominant T cell epitopes of the timothy grass pollen allergen Phl p 5b were identified. By...
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