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Article

Gfi-1 represses <i>CDKN2B</i> encoding p15 <sup>INK4B</sup> through interaction with Miz-1

22 Jan 2009

Abstract excerpt

Gfi-1 is a nuclear zinc finger (ZF) transcriptional repressor that plays an important role in hematopoiesis and inner ear development, and has been implicated in lymphomagenesis. Gfi-1 represses transcription by directly binding to the consensus DNA sequence in the promoters of its target genes. We report here an alternative mechanism by which Gfi-1 represses CDKN2B encoding p15(INK4B). Gfi-1 does not directly...

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PMID: 19164764
DOI: 10.1073/pnas.0804863106

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