Article

KLF4/MLL3 axis Drives NRBP2 Transcription to Eliminate Acute Myeloid Leukemia Cells

2025-09-30

Abstract excerpt

<title>Abstract</title> <p>Acute myeloid leukemia (AML) is a heterogeneous malignancy rooted in hematopoietic stem cell dysregulation. Despite therapeutic advances, clinical outcomes remain unsatisfactory. Here, we identify KLF4, a zinc finger transcription factor with previously reported context-dependent roles in hematologic malignancies, as a negative regulator of AML proliferation. Mechanistically, KLF4 inter...

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Literature Corpus work: e9229447-b187-5d4c-bf30-a163dfa5d1d7
DOI: 10.21203/rs.3.rs-7639334/v1

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