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Article

Identification of PHRF1 as a Tumor Suppressor that Promotes the TGF-β Cytostatic Program through Selective Release of TGIF-Driven PML Inactivation

1 Aug 2013

Abstract excerpt

The homeodomain protein TGIF (TG-interacting factor) restricts TGF-β/Smad cytostatic signaling by interfering with the nucleocytoplasmic transit of the tumor suppressor cPML. Here, we identify PHRF1 as a ubiquitin ligase that enforces TGIF decay by driving its ubiquitination at lysine 130. In so doing, PHRF1 ensures redistribution of cPML into the cytoplasm, where it associates with SARA and coordinates...

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Identifiers

PMID: 23911286
DOI: 10.1016/j.celrep.2013.07.009

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