Article
Somatic mutations in CCK2R alter receptor activity that promote oncogenic phenotypes.
Molecular cancer research : MCR - 1 Jun 2012
Willard Melinda D, Lajiness Mary E, Wulur Isabella H, Feng Bo, Swearingen Michelle L, Uhlik Mark T, Kinzler Kenneth W, Velculescu Victor E, Sjöblom Tobias, Markowitz Sanford D, Powell Steven M, Vogelstein Bert, Barber Thomas D
Abstract excerpt
The roles of cholecystokinin 2 receptor (CCK2R) in numerous physiologic processes in the gastrointestinal tract and central nervous system are well documented. There has been some evidence that CCK2R alterations play a role in cancers, but the functional significance of these alterations for tumorigenesis is unknown. We have identified six mutations in CCK2R among a panel of 140 colorectal cancers and 44 gastric...
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