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Article

Rab27b localizes to the tubulovesicle membranes of gastric parietal cells and regulates acid secretion.

Gastroenterology - 1 Mar 2011

Suda Jo, Zhu Lixin, Okamoto Curtis T, Karvar Serhan

Abstract excerpt

BACKGROUND & AIMS: Rabs are monomeric guanosine triphosphatases that regulate membrane trafficking and acid secretion in gastric parietal cells. Using a proteomics approach, we identified a new Rab, Rab27b, in tubulovesicle membranes and determined its role in parietal cell activation. METHODS: We used mass spectrometry (MS) to identify Rab27b in purified tubulovesicular membrane fractions and used immunoblot and...

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Share to Gastric Acid
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 20888820
DOI: 10.1053/j.gastro.2010.09.044

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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