Article
C. elegans tubby regulates life span and fat storage by two independent mechanisms.
Cell metabolism - 1 Jul 2005
Mukhopadhyay Arnab, Deplancke Bart, Walhout Albertha J M, Tissenbaum Heidi A
Abstract excerpt
In C. elegans, similar to in mammals, mutations in the tubby homolog, tub-1, promote increased fat deposition. Here, we show that mutation in tub-1 also leads to life span extension dependent on daf-16/FOXO. Interestingly, function of tub-1 in fat storage is independent of daf-16. A yeast two-hyb...
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