Article
BCL10 single nucleotide polymorphism and its association with CSF dissemination of primary intracranial germ cell tumors.
Pediatric neurosurgery - 1 Jan 2009
Hayashi Yutaka, Watanabe Takuya, Nakada Mitsutoshi, Kita Daisuke, Hayashi Yasuhiko, Uchiyama Naoyuki, Hamada Jun-ichiro
Abstract excerpt
BACKGROUND: Intracranial germ cell tumors (GCTs) are rare neoplasms. Little is known about the pathogenesis of these tumors. The BCL10 gene, a proapoptotic signaling molecule involved in the Apaf-1/caspase-9 cell death pathway, may act as a tumor suppressor gene in multiple types of tumors including testicular GCTs. METHODS: To evaluate whether alterations in the BCL10 gene play a role in the genesis of...
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