Article
IL-10 -1082 SNP and IL-10 in primary CNS and vitreoretinal lymphomas.
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie - 1 Oct 2012
Ramkumar Hema L, Shen De Fen, Tuo Jingsheng, Braziel Rita M, Coupland Sarah E, Smith Justine R, Chan Chi-Chao
Abstract excerpt
OBJECTIVES: Most primary central nervous system lymphomas (PCNSLs) and primary vitreoretinal lymphomas (PVRLs) are B-cell lymphomas that produce high levels of interleukin (IL)-10, which is linked to rapid disease progression. The IL-10 (-1082) G → A polymorphism (IL-10 SNP) is associated with improved survival in certain non-CNS lymphoma patients. PDCD4 is a tumor suppressor gene and upstream...
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