Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

MicroRNA 143-145 deficiency impairs vascular function.

International journal of immunopathology and pharmacology - 1 Jan 2000

Norata G D, Pinna C, Zappella F, Elia L, Sala A, Condorelli G, Catapano A L

Abstract excerpt

MicroRNAs are required for vascular smooth muscle growth, differentiation and function. MiR143-145 modulates cytoskeletal dynamics and acquisition of the contractile phenotype by smooth muscle cells. Lack of this miRNA cluster results in decreased blood pressure and reduced vasocontraction. As all these observations point to a key role for miR143-145 in the vasculature, we investigated whether miR143-145...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aorta, Thoracic
Share to Down-Regulation
Share to Muscle, Smooth, Vascular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Myocytes, Smooth Muscle

Share to Vasoconstriction

Share to Vasoconstrictor Agents

Share to Vasodilation

Share to Vasodilator Agents

Source

Identifiers

PMID: 22697078
DOI: 10.1177/039463201202500216

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

MicroRNA 143-145 deficiency impairs vascular function.PMID 22697078Read ↗

Induction of angiotensin-converting enzyme after miR-143/145 deletion is critical for impaired smooth muscle contractility.Semantic proximity Read ↗

MicroRNA-modulated targeting of vascular smooth muscle cells.Semantic proximity Read ↗

MiR-143/145 deficiency attenuates the progression of atherosclerosis in Ldlr-/-mice.Semantic proximity Read ↗

Acquisition of the contractile phenotype by murine arterial smooth muscle cells depends on the Mir143/145 gene cluster.Semantic proximity Read ↗

Can microRNAs control vascular smooth muscle phenotypic modulation and the response to injury?Semantic proximity Read ↗

Phenotypic switching of vascular smooth muscle cells in the 'normal region' of aorta from atherosclerosis patients is regulated by miR-145.Semantic proximity Read ↗

MicroRNA-145, a novel smooth muscle cell phenotypic marker and modulator, controls vascular neointimal lesion formation.Semantic proximity Read ↗

Differential expression of vascular smooth muscle-modulating microRNAs in human peripheral blood mononuclear cells: novel targets in essential hypertension.Semantic proximity Read ↗

MicroRNAs miR-143 and miR-145 modulate cytoskeletal dynamics and responsiveness of smooth muscle cells to injury.Semantic proximity Read ↗

miR-143 and miR-145: molecular keys to switch the phenotype of vascular smooth muscle cells.Semantic proximity Read ↗

The miR-143/145 cluster reverses the regulation effect of KLF5 in smooth muscle cells with proliferation and contractility in intracranial aneurysm.Semantic proximity Read ↗

rs41291957 controls miR-143 and miR-145 expression and impacts coronary artery disease risk.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.