Article
Structure of the restriction-modification controller protein C.Esp1396I.
Acta crystallographica. Section D, Biological crystallography - 1 Sept 2009
Ball N, Streeter S D, Kneale G G, McGeehan J E
Abstract excerpt
The controller protein of the Esp1396I restriction-modification (R-M) system binds differentially to three distinct operator sequences upstream of the methyltransferase (M) and endonuclease (R) genes to regulate the timing of gene expression. The crystal structure of a complex of the protein with two adjacent operator DNA sequences has been reported; however, the structure of the free protein has not yet been...
Topics
- Bacteria
- Crystallization
- DNA Restriction-Modification Enzymes
- DNA-Binding Proteins
- Dimerization
- Gene Expression Regulation, Bacterial
- Helix-Turn-Helix Motifs
- Multiprotein Complexes
- Mutation
- Protein Binding