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Article

Structural and mutagenic analysis of the RM controller protein C.Esp1396I.

PloS one - 1 Jan 2014

Martin Richard N A, McGeehan John E, Kneale Geoff

Abstract excerpt

Bacterial restriction-modification (RM) systems are comprised of two complementary enzymatic activities that prevent the establishment of foreign DNA in a bacterial cell: DNA methylation and DNA restriction. These two activities are tightly regulated to prevent over-methylation or auto-restriction. Many Type II RM systems employ a controller (C) protein as a transcriptional regulator for the endonuclease gene...

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PMID: 24887147
DOI: 10.1371/journal.pone.0098365
PMCID: PMC4041747

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