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Article

The DNA binding domain of the Vibrio vulnificus SmcR transcription factor is flexible and binds diverse DNA sequences.

Nucleic acids research - 4 Jun 2021

Newman Jane D, Russell Meghan M, Fan Lixin, Wang Yun-Xing, Gonzalez-Gutierrez Giovanni, van Kessel Julia C

Abstract excerpt

Quorum sensing gene expression in vibrios is regulated by the LuxR/HapR family of transcriptional factors, which includes Vibrio vulnificus SmcR. The consensus binding site of Vibrio LuxR/HapR/SmcR proteins is palindromic but highly degenerate with sequence variations at each promoter. To examine the mechanism by which SmcR recognizes diverse DNA sites, we generated SmcR separation-of-function mutants that either...

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Identifiers

PMID: 34023896
DOI: 10.1093/nar/gkab387
PMCID: PMC8191795

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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